Neosorb PGLA Synthetic Absorbable Surgical Suture (PGLA) elicits a minimal acute inflammatory reaction in tissues, which is followed by gradual encapsulation of the suture by fibrous connective tissue. Progressive loss of tensile strength and eventual absorption of PGLA absorbable sutures occurs hydrolysis, where the polymer degrades to glycolic and lactic acids which are subsequently absorbed and metabolized in the body.

Absorption begins as a loss of tensile strength without appreciable loss of mass. PGLA retains approximately 50% of the average E.P. tensile strength requirement at the end of the 2nd post implantation week. The absorption of the suture is essentially complete between 56-70 days.